CYP2A7

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYP2A7 mutation is significantly associated with the RNA expression of many other genes, with 659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2A7-associated genes across cancer lineages are RNU4-45P, RNU6-1318P, and RN7SL616P. Each is linked with CYP2A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2A7-to-partner and partner-to-CYP2A7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A7→partner) and Y-score (partner→CYP2A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCRNU4-45P →+0.175+4.757<.001.00432
READRNU6-1318P →+0.446+4.533.002.00432
CESCRN7SL616P →+0.107+4.559<.001.00632
CESCMIR3135A →+0.654+4.918<.001<.00132
BRCAMIR572 →+0.336+6.234<.001<.00132
BRCARN7SL191P →+0.190+4.683<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 659 associations by consensus.

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