Across TCGA pan-cancer cohorts, CYP2A7 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CYP2A7’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CYP2A7 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2A7 is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

LIHC, CHOL, and LUSC are the cancer types where CYP2A7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2A7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	−3.593	<.001	8	view →
CHOL	Female	All	−7.246	<.001	5	view →
LUSC	Male	All	−0.166	<.001	4	view →
UCEC	All	All	−0.228	.013	2	view →
LUAD	Female	All	−0.122	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CYP2A7 RNA expression & survival · all CYP2A7 data types