Across TCGA patient cohorts, CYP2A7 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2A7-associated genes across cancer lineages are MEK1, ATM, and Fibronectin. Each is linked with CYP2A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2A7-to-partner and partner-to-CYP2A7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A7→partner) and Y-score (partner→CYP2A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.503	+2.459	.004	.020	3	2
UCEC	ATM →	-0.724	-3.584	<.001	.002	3	2
STAD	Fibronectin →	+0.403	+2.828	.031	.035	3	1
UCEC	IGFBP2 →	-0.777	-2.459	.013	.020	3	1
UCEC	MSH2 →	-0.316	-3.160	.004	.019	3	1
UCEC	Myosin-IIa →	+0.246	+2.177	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

CYP2A7 survival (RNA) · tumor vs normal (RNA) · all CYP2A7 data types