Across TCGA cell cohorts, CYP2A7 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible CYP2A7-associated genes across cancer lineages are C16orf78, OR2A5, and H3C11. Each is linked with CYP2A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2A7-to-partner and partner-to-CYP2A7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A7→partner) and Y-score (partner→CYP2A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C16orf78 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2A5 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	H3C11 →	+0.416	+4.807	<.001	.006	3	1
OESOPHAGUS	PRDM14 →	+0.006	+4.017	<.001	.007	3	1
OESOPHAGUS	SERPINA11 →	+0.021	+4.392	.001	.003	3	1
OESOPHAGUS	GLYATL3 →	+0.073	+4.017	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

CYP2A7 survival (RNA) · tumor vs normal (RNA) · all CYP2A7 data types