CYP26A1

Across TCGA cell cohorts, CYP26A1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP26A1-associated genes across cancer lineages are KLHL40, CST9, and MRGPRG. Each is linked with CYP26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26A1-to-partner and partner-to-CYP26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by CYP26A1-low versus CYP26A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26A1→partner) and Y-score (partner→CYP26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRG →	+0.056	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CLPSL1 →	+0.154	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR4E1 →	+0.022	+5.209	<.001	.005	3	1
LARGE_INTESTINE	RFX4 →	+0.046	+3.029	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KLHL40 by CYP26A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →