CYP26A1

Across TCGA pan-cancer cohorts, CYP26A1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CYP26A1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CYP26A1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYP26A1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

KIRC, ACC, and KIRP are the cancer types where CYP26A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.534	0.719	<.001	130	view →
ACC	DFS	Median	All	0.203	0.660	<.001	49	view →
KIRP	OS	Median	All	0.885	0.973	<.001	48	view →
STAD	OS	Tertile	II,III,IV	0.532	0.716	.007	30	view →
CESC	OS	Tertile	All	0.679	0.478	.011	28	view →
LUSC	DFS	Tertile	All	0.807	0.677	.002	21	view →
HNSC	DFS	Median	IV	0.716	0.562	.004	19	view →
TGCT	DFS	Quartile	All	0.523	0.897	.007	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	16	view →
PAAD	OS	Tertile	All	0.233	0.616	.003	11	view →
CHOL	OS	Quartile	All	0.773	0.305	.033	10	view →
READ	DFS	Quartile	III,IV	0.507	0.872	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CYP26A1–KIRC (OS)

Open the KIRC breakdown →