CYP1B1-AS1

Across TCGA patient cohorts, CYP1B1-AS1 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1B1-AS1-associated genes across cancer lineages are RNA5SP389, RNA5SP326, and RNA5SP60. Each is linked with CYP1B1-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1B1-AS1-to-partner and partner-to-CYP1B1-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP389 grouped by CYP1B1-AS1-low versus CYP1B1-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1B1-AS1→partner) and Y-score (partner→CYP1B1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP389 →	+2.711	+5.616	<.001	<.001	3	2
UCEC	RNA5SP326 →	+1.788	+4.771	<.001	.006	3	2
UCEC	RNA5SP60 →	+2.180	+4.937	<.001	.005	3	2
BRCA	RNA5-8SN2 →	+0.433	+5.950	<.001	.001	3	1
BRCA	PRNT →	+0.029	+5.311	<.001	.001	3	1
BRCA	RNU6-1027P →	+0.487	+4.721	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

RNA5SP389 by CYP1B1-AS1 expression — UCEC

Explore this box plot interactively →