CYP1B1-AS1

Across TCGA pan-cancer cohorts, CYP1B1-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CYP1B1-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CYP1B1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYP1B1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THCA show a favorable association.

KIRP, ACC, and KIRC are the cancer types where CYP1B1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.857	0.969	<.001	123	view →
ACC	OS	Median	II,III,IV	0.749	0.945	<.001	64	view →
KIRC	OS	Median	All	0.545	0.706	<.001	63	view →
ESCA	OS	Tertile	III,IV	0.661	0.320	.001	59	view →
THCA	DFS	Tertile	II,III,IV	0.956	0.795	<.001	56	view →
LUAD	OS	Quartile	All	0.777	0.596	<.001	51	view →
LIHC	OS	Median	All	0.884	0.672	<.001	37	view →
MESO	DFS	Tertile	IV	0.517	0.105	.001	24	view →
GBM	DFS	Median	All	0.205	0.304	.010	24	view →
LAML	DFS	Median	All	0.263	0.518	.009	22	view →
CHOL	DFS	Median	All	0.683	0.122	.008	21	view →
OV	DFS	Median	IV	0.337	0.558	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CYP1B1-AS1–KIRP (OS)

Open the KIRP breakdown →