CYLD

Across TCGA cell cohorts, CYLD mutation is significantly associated with the RNA expression of many other genes, with 885 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYLD-associated genes across cancer lineages are LRRC74A, SERPINA7, and C1orf158. Each is linked with CYLD in more than 1 cancer types. Because this analysis shows association rather than direction, both CYLD-to-partner and partner-to-CYLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC74A grouped by CYLD-low versus CYLD-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLD→partner) and Y-score (partner→CYLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LRRC74A →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	F9 →	+0.022	+4.523	.001	.004	3	1
LUNG_SCLC	OR4E2 →	+0.016	+5.029	<.001	.006	3	1
LUNG_SCLC	CT47A1 →	+0.243	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 885 associations by consensus.

LRRC74A by CYLD expression — BLOOD_Myeloma

Explore this box plot interactively →