CYLD

Across TCGA pan-cancer cohorts, CYLD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYLD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYLD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYLD is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where CYLD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYLD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.604	<.001	11	view →
THCA	Male	All	−0.835	<.001	9	view →
COAD	Female	All	−0.609	<.001	8	view →
HNSC	All	All	+0.331	.004	7	view →
UCEC	All	All	−0.846	<.001	6	view →
LUSC	Female	All	−0.803	<.001	6	view →
BLCA	Female	All	−0.702	.004	5	view →
LUAD	Female	II,III,IV	−0.406	.006	5	view →
LIHC	All	All	+0.322	.001	5	view →
READ	All	All	−0.653	.011	2	view →
KICH	All	All	−0.399	.006	2	view →
PRAD	All	All	−0.269	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYLD–KIRC

Open the KIRC breakdown →