CYLC2

Across TCGA patient cohorts, CYLC2 mutation is significantly associated with the RNA expression of many other genes, with 2,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLC2-associated genes across cancer lineages are LINC01848, WDHD1, and RN7SL159P. Each is linked with CYLC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYLC2-to-partner and partner-to-CYLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01848 grouped by CYLC2-low versus CYLC2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC2→partner) and Y-score (partner→CYLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC01848 →	+0.192	+3.963	<.001	.003	3	4
UCEC	WDHD1 →	+0.562	+1.609	.001	.005	3	4
LIHC	RN7SL159P →	+0.103	+4.149	<.001	.009	3	3
UCEC	PAMR1 →	-0.825	-2.646	.003	<.001	3	3
UCEC	ADAM33 →	-0.753	-2.854	.003	.001	3	3
UCEC	CHAF1B →	+0.632	+1.679	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

LINC01848 by CYLC2 expression — HNSC

Explore this box plot interactively →