CYLC2

Across TCGA patient cohorts, CYLC2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLC2-associated genes across cancer lineages are Shc_pY317, Cyclin-B1, and ASNS. Each is linked with CYLC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYLC2-to-partner and partner-to-CYLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CYLC2-low versus CYLC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC2→partner) and Y-score (partner→CYLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.155	-1.736	.003	.007	3	3
UCEC	Cyclin-B1 →	+0.706	+2.070	<.001	.001	3	3
COAD	ASNS →	+0.843	+2.815	<.001	.036	3	2
COAD	C-Raf →	+0.216	+2.815	.007	.036	3	2
COAD	Cyclin-E2 →	+0.261	+2.815	.040	.036	1	4
SKCM	IGFBP2 →	-0.410	-2.087	.036	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Shc_pY317 by CYLC2 expression — UCEC

Explore this box plot interactively →