CYLC2

Across TCGA cell cohorts, CYLC2 RNA expression is significantly associated with the mutation status of many other genes, with 102 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CYLC2-associated genes across cancer lineages are ZNF618, PHKA2, and DOCK5. Each is linked with CYLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYLC2-to-partner and partner-to-CYLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF618 grouped by CYLC2-low versus CYLC2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC2→partner) and Y-score (partner→CYLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF618 →	+4.357	+0.012	.006	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	PHKA2 →	+4.357	+0.012	.006	<.001	3	2
BLOOD_Myeloma	DOCK5 →	+3.754	+0.026	.002	<.001	3	1
BLOOD_Myeloma	FMN2 →	+3.169	+0.021	.004	<.001	3	1
BLOOD_Myeloma	ATP13A5 →	+3.754	+0.026	.002	<.001	3	1
LUNG_SCLC	MYH3 →	+4.169	+0.011	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

ZNF618 by CYLC2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →