CYLC2

Across TCGA cell cohorts, CYLC2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYLC2-associated genes across cancer lineages are IL31, APOBEC1, and CLRN2. Each is linked with CYLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYLC2-to-partner and partner-to-CYLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by CYLC2-low versus CYLC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLC2→partner) and Y-score (partner→CYLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.015	+2.977	<.001	.006	3	2
BONE	APOBEC1 →	+0.026	+5.169	<.001	.004	3	1
BONE	CLRN2 →	+0.026	+5.169	<.001	.004	3	1
SKIN	HNRNPCL4 →	+0.037	+2.672	<.001	.004	3	1
SKIN	OR56A1 →	+0.009	+2.977	<.001	.006	3	1
SKIN	OR4F5 →	+0.026	+4.131	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IL31 by CYLC2 expression — SKIN

Explore this box plot interactively →