CYBRD1

Across TCGA patient cohorts, CYBRD1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYBRD1-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and p38-MAPK_pT180_Y182. Each is linked with CYBRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYBRD1-to-partner and partner-to-CYBRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CYBRD1-low versus CYBRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBRD1→partner) and Y-score (partner→CYBRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.128	-3.160	.041	.019	3	1
UCEC	Ku80 →	+0.280	+3.472	.018	.002	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.469	-3.169	.038	.019	3	1
UCEC	TIGAR →	+0.163	+2.348	.033	.019	3	1
UCEC	XBP1 →	-0.180	-2.321	.011	.035	3	1
UCEC	Bax →	+0.280	+3.179	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a_pS318_S321 by CYBRD1 expression — UCEC

Explore this box plot interactively →