CYBRD1

Across TCGA pan-cancer cohorts, CYBRD1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CYBRD1 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CYBRD1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYBRD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

LGG, OV, and KIRP are the cancer types where CYBRD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.368	0.537	<.001	54	view →
OV	OS	Tertile	III,IV	0.250	0.382	<.001	48	view →
KIRP	OS	Median	II,III,IV	0.241	0.695	.003	39	view →
HNSC	DFS	Quartile	IV	0.767	0.520	.002	36	view →
SKCM	OS	Tertile	II,III,IV	0.428	0.275	.004	33	view →
BLCA	DFS	Quartile	II,III,IV	0.269	0.480	.006	33	view →
MESO	OS	Median	All	0.478	0.314	.022	23	view →
ESCA	DFS	Quartile	All	0.671	0.405	.003	21	view →
CHOL	DFS	Tertile	All	0.747	0.150	.001	21	view →
LUAD	OS	Median	II,III,IV	0.691	0.497	.008	19	view →
LIHC	DFS	Median	III,IV	0.554	0.268	.006	12	view →
SARC	DFS	Tertile	All	0.683	0.532	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CYBRD1–LGG (OS)

Open the LGG breakdown →