CYBRD1

Across TCGA pan-cancer cohorts, CYBRD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYBRD1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CYBRD1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYBRD1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and COAD are the cancer types where CYBRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYBRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.478	<.001	11	view →
THCA	Male	III,IV	−1.481	<.001	11	view →
COAD	Female	II,III,IV	−2.201	<.001	10	view →
BLCA	Male	III,IV	−3.157	<.001	8	view →
LUSC	Female	All	−2.456	<.001	8	view →
KIRP	All	All	−1.476	<.001	7	view →
KIRC	All	II,III,IV	−0.730	<.001	7	view →
UCEC	All	All	−3.208	<.001	6	view →
BRCA	All	II,III,IV	−1.142	<.001	6	view →
KICH	All	All	−1.724	<.001	5	view →
STAD	All	All	−1.505	<.001	5	view →
READ	Female	All	−2.906	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYBRD1–LUAD

Open the LUAD breakdown →