CYBB

Across TCGA patient cohorts, CYBB RNA expression is significantly associated with the protein abundance of many other proteins, with 21,370 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYBB-associated proteins across cancer lineages are ARHGAP45, PLCB2, and PLEKHO2. Each is linked with CYBB in more than 9 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYBB versus ARHGAP45 in GBM, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.685	+0.900	<.001	<.001	3	10
GBM	PLCB2 →	+0.720	+1.182	<.001	<.001	3	10
OV	PLEKHO2 →	+0.504	+1.663	<.001	<.001	3	10
LSCC	PLEKHO2_T311 →	+0.578	+0.935	<.001	<.001	3	10
LSCC	ARHGEF6 →	+0.527	+1.048	<.001	<.001	3	10
HNSC	ARHGEF6_S225 →	+0.941	+1.458	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,370 associations by consensus.

CYBB vs ARHGAP45 — GBM

Explore this scatter interactively →