CYBB

Across TCGA pan-cancer cohorts, CYBB RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CYBB data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CYBB RNA is associated with better overall survival. In most high-consensus cancer types, elevated CYBB expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and CESC are the cancer types where CYBB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.414	0.262	<.001	105	view →
HNSC	DFS	Tertile	All	0.718	0.528	<.001	75	view →
CESC	DFS	Median	II,III,IV	0.815	0.565	<.001	40	view →
UCEC	OS	Tertile	III,IV	0.761	0.443	.008	38	view →
LUAD	DFS	Median	All	0.716	0.615	.004	33	view →
LGG	DFS	Tertile	All	0.663	0.831	<.001	33	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	24	view →
KIRC	DFS	Median	All	0.851	0.735	.010	21	view →
CHOL	DFS	Median	All	0.623	0.196	.010	15	view →
MESO	OS	Tertile	All	0.405	0.282	.026	12	view →
ACC	OS	Quartile	III,IV	0.130	0.829	.006	12	view →
GBM	DFS	Quartile	All	0.175	0.306	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CYBB–SKCM (OS)

Open the SKCM breakdown →