CYBB

Across TCGA pan-cancer cohorts, CYBB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CYBB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYBB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYBB is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where CYBB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYBB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.271	<.001	12	view →
KIRP	Female	All	+1.542	<.001	11	view →
LUAD	All	II,III,IV	−1.312	<.001	10	view →
LUSC	Male	II,III,IV	−2.311	<.001	8	view →
HNSC	Female	All	+1.420	.001	7	view →
STAD	All	All	+1.166	<.001	7	view →
THCA	Male	II,III,IV	+1.296	.007	5	view →
ESCA	All	All	+1.537	.017	2	view →
UCEC	All	All	−0.897	.004	2	view →
READ	Female	All	−1.278	.022	1	view →
LIHC	Male	All	−0.664	.034	1	view →
COAD	All	All	−0.449	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CYBB–KIRC

Open the KIRC breakdown →