CYBB

Across TCGA patient cohorts, CYBB protein abundance is significantly associated with the RNA expression of many other genes, with 18,956 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYBB-associated genes across cancer lineages are CYTH4, CSF2RB, and SIRPB1. Each is linked with CYBB in more than 9 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYBB versus CYTH4 in GBM, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.076	+0.802	<.001	<.001	3	10
UCEC	CSF2RB →	+1.280	+1.148	<.001	<.001	3	10
OV	SIRPB1 →	+0.679	+0.720	<.001	<.001	3	10
UCEC	HCK →	+1.266	+1.210	<.001	<.001	3	10
UCEC	TLR8 →	+1.140	+1.044	<.001	<.001	3	10
UCEC	IL4I1 →	+1.329	+0.766	<.001	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,956 associations by consensus.

CYBB vs CYTH4 — GBM

Explore this scatter interactively →