CYBB

Across TCGA patient cohorts, CYBB protein abundance is significantly associated with the protein abundance of many other proteins, with 27,333 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYBB-associated proteins across cancer lineages are ARHGAP25, ARHGAP25_S363, and ARHGAP30. Each is linked with CYBB in more than 9 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYBB versus ARHGAP25 in OV, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP25 →	+0.808	+0.691	.002	.002	3	10
LSCC	ARHGAP25_S363 →	+0.716	+0.689	<.001	<.001	3	10
GBM	ARHGAP30 →	+0.741	+0.810	<.001	<.001	3	10
BRCA	ACAP1 →	+0.694	+0.963	<.001	<.001	3	10
GBM	ARHGAP4 →	+0.673	+0.888	<.001	<.001	3	10
GBM	ARHGAP45 →	+0.693	+0.762	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 27,333 associations by consensus.

CYBB vs ARHGAP25 — OV

Explore this scatter interactively →