CYBB

Across TCGA patient cohorts, CYBB mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYBB-associated genes across cancer lineages are p70-S6K, Di-Ras3, and Notch1. Each is linked with CYBB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by CYBB-low versus CYBB-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p70-S6K →	+0.234	+3.459	.022	.005	3	2
UCEC	Di-Ras3 →	-0.129	-1.947	.004	<.001	3	2
UCEC	Notch1 →	+0.111	+1.473	.010	.006	3	2
UCEC	PDCD4 →	-0.371	-1.492	.010	.027	3	2
UCEC	Rab25 →	-0.278	-2.906	.006	.001	3	2
UCEC	Annexin-1 →	+0.453	+1.785	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

p70-S6K by CYBB expression — LUSC

Explore this box plot interactively →