CYBB

Across TCGA cell cohorts, CYBB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,309 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYBB-associated GO terms across cancer lineages are Post-transcriptional gene silencing, Negative regulation of syncytium formation by plasma membrane fusion, and Negative regulation of RNA splicing. Each is linked with CYBB in more than 7 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional gene silencing grouped by CYBB-low versus CYBB-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Post-transcriptional gene silencing →	+0.093	+0.392	.001	<.001	3	8
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.101	<.001	.001	3	7
BONE	Negative regulation of RNA splicing →	+0.084	+0.113	<.001	.009	3	7
BLOOD_Lymphoma	Response to molecule of fungal origin →	+1.545	+3.210	<.001	<.001	3	6
BLOOD_Lymphoma	Cellular response to molecule of fungal origin →	+1.545	+3.210	<.001	<.001	3	6
BLOOD_Lymphoma	Positive regulation of DNA repair →	+0.060	+3.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,309 associations by consensus.

Post-transcriptional gene silencing by CYBB expression — LUNG_SCLC

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