CYBB

Across TCGA cell cohorts, CYBB mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYBB-associated genes across cancer lineages are SSX5, IL25, and TGM6. Each is linked with CYBB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYBB-to-partner and partner-to-CYBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX5 grouped by CYBB-low versus CYBB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBB→partner) and Y-score (partner→CYBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SSX5 →	+0.063	+3.672	<.001	.006	3	1
BREAST	IL25 →	+0.023	+3.672	<.001	.006	3	1
BREAST	TGM6 →	+0.021	+4.312	<.001	.001	3	1
BREAST	OR52A1 →	+0.022	+3.672	<.001	.006	3	1
BREAST	KRT76 →	+0.006	+4.064	<.001	.003	3	1
BREAST	SLC36A2 →	+0.454	+3.825	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SSX5 by CYBB expression — BREAST

Explore this box plot interactively →