CYBA

Across TCGA cell cohorts, CYBA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYBA-associated genes across cancer lineages are SLC6A17, OR4F5, and FAM170A. Each is linked with CYBA in more than 1 cancer types. Because this analysis shows association rather than direction, both CYBA-to-partner and partner-to-CYBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A17 grouped by CYBA-low versus CYBA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBA→partner) and Y-score (partner→CYBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC6A17 →	+0.213	+4.037	<.001	.004	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	FAM170A →	+0.131	+3.070	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SLC6A17 by CYBA expression — BLOOD_Leukemia

Explore this box plot interactively →