CYBA

Across TCGA pan-cancer cohorts, CYBA RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CYBA data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher CYBA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYBA expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRP show a favorable association.

UCS, LUSC, and KIRC are the cancer types where CYBA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.225	0.613	.004	86	view →
LUSC	OS	Tertile	II,III,IV	0.503	0.704	<.001	78	view →
KIRC	OS	Median	All	0.557	0.700	<.001	54	view →
UCEC	DFS	Tertile	All	0.729	0.476	<.001	52	view →
LGG	DFS	Median	All	0.301	0.495	<.001	50	view →
KIRP	DFS	Median	II,III,IV	0.875	0.654	.004	48	view →
ACC	OS	Median	III,IV	0.557	0.916	<.001	43	view →
UVM	OS	Quartile	All	0.344	0.909	.010	24	view →
LAML	DFS	Quartile	All	0.327	0.575	.006	24	view →
CHOL	OS	Median	All	0.843	0.397	.008	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
SCLC	DFS	Quartile	All	0.782	0.426	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CYBA–UCS (OS)

Open the UCS breakdown →