CYBA

Across TCGA pan-cancer cohorts, CYBA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CYBA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYBA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYBA is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where CYBA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYBA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.422	<.001	12	view →
KIRP	Male	II,III,IV	+1.791	<.001	9	view →
KICH	Female	II,III,IV	−2.625	<.001	8	view →
STAD	All	All	+1.635	<.001	7	view →
BLCA	All	All	+0.976	.003	7	view →
UCEC	All	All	+1.114	.004	6	view →
HNSC	Male	All	+0.832	<.001	6	view →
LUSC	All	All	−0.633	<.001	6	view →
CHOL	All	All	+3.328	<.001	5	view →
THCA	All	All	+0.528	<.001	5	view →
ESCA	All	All	+1.993	.003	4	view →
LIHC	Female	II,III,IV	+1.417	.014	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CYBA–KIRC

Open the KIRC breakdown →