CYB5R4

Across TCGA patient cohorts, CYB5R4 mutation is significantly associated with the RNA expression of many other genes, with 3,118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R4-associated genes across cancer lineages are COX6CP4, TMEM97, and IFNWP5. Each is linked with CYB5R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R4-to-partner and partner-to-CYB5R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP4 grouped by CYB5R4-low versus CYB5R4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R4→partner) and Y-score (partner→CYB5R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COX6CP4 →	+1.379	+5.800	<.001	.003	3	2
SKCM	TMEM97 →	+0.872	+3.214	.002	.009	3	2
LUAD	IFNWP5 →	+0.037	+4.523	<.001	.004	3	2
UCEC	KCNK15 →	-1.357	-3.076	<.001	<.001	3	2
STAD	MIR4276 →	+0.474	+5.366	<.001	.005	3	2
STAD	RNU1-57P →	+0.725	+5.026	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,118 associations by consensus.

COX6CP4 by CYB5R4 expression — BRCA

Explore this box plot interactively →