CYB5R4

Across TCGA pan-cancer cohorts, CYB5R4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CYB5R4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYB5R4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYB5R4 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where CYB5R4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYB5R4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.709	<.001	12	view →
KIRC	Male	All	+0.448	<.001	9	view →
STAD	All	II,III,IV	+0.593	<.001	7	view →
LIHC	Male	All	+0.496	<.001	7	view →
CHOL	All	All	+1.311	<.001	5	view →
KICH	All	All	−0.691	<.001	5	view →
BRCA	All	II,III,IV	+0.230	.002	4	view →
THCA	Female	All	−0.349	<.001	3	view →
BLCA	Male	IV	+0.472	.001	2	view →
ESCA	All	All	+0.754	.008	1	view →
READ	Female	All	−0.434	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CYB5R4–HNSC

Open the HNSC breakdown →