CYB5R4

Across TCGA cell cohorts, CYB5R4 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB5R4-associated genes across cancer lineages are VSX2, OR2K2, and ITGAD. Each is linked with CYB5R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R4-to-partner and partner-to-CYB5R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSX2 grouped by CYB5R4-low versus CYB5R4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R4→partner) and Y-score (partner→CYB5R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSX2 →	+0.011	+2.257	.008	.009	3	2
LARGE_INTESTINE	OR2K2 →	+0.016	+2.510	.009	.004	3	2
BREAST	ITGAD →	+0.120	+4.199	<.001	.007	3	2
BREAST	KRTAP21-2 →	+0.417	+4.199	<.001	.007	3	2
LARGE_INTESTINE	PIH1D1 →	+0.655	+3.212	<.001	.006	3	1
LARGE_INTESTINE	FAM149A →	+1.493	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

VSX2 by CYB5R4 expression — LARGE_INTESTINE

Explore this box plot interactively →