CYB5R2

Across TCGA patient cohorts, CYB5R2 mutation is significantly associated with the RNA expression of many other genes, with 1,981 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R2-associated genes across cancer lineages are RNU4-4P, NCOA4P1, and TAF13P2. Each is linked with CYB5R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R2-to-partner and partner-to-CYB5R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-4P grouped by CYB5R2-low versus CYB5R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R2→partner) and Y-score (partner→CYB5R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-4P →	+0.322	+2.319	.004	.003	3	2
SKCM	NCOA4P1 →	+0.043	+4.188	<.001	.009	3	2
SKCM	TAF13P2 →	+0.112	+4.513	<.001	.009	3	2
THCA	SCML2P1 →	+0.029	+7.962	<.001	.007	3	1
THCA	SNORD114-14 →	+0.332	+7.962	<.001	.007	3	1
THCA	RNU11-5P →	+0.203	+7.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,981 associations by consensus.

RNU4-4P by CYB5R2 expression — UCEC

Explore this box plot interactively →