CYB5R2

Across TCGA pan-cancer cohorts, CYB5R2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CYB5R2 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CYB5R2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYB5R2 expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

LGG, LUSC, and LAML are the cancer types where CYB5R2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.746	0.870	<.001	43	view →
LUSC	OS	Quartile	II,III,IV	0.549	0.264	<.001	42	view →
LAML	DFS	Quartile	All	0.433	0.709	.004	28	view →
OV	OS	Quartile	All	0.373	0.282	.022	26	view →
HNSC	OS	Median	IV	0.674	0.530	.005	18	view →
KIRP	DFS	Tertile	IV	0.050	0.765	.010	18	view →
LIHC	OS	Tertile	II,III,IV	0.419	0.733	.001	17	view →
GBM	DFS	Median	All	0.214	0.296	.023	16	view →
UVM	DFS	Tertile	II,III,IV	0.639	0.987	.015	16	view →
STAD	DFS	Tertile	IV	0.101	0.524	.017	15	view →
MESO	OS	Tertile	All	0.416	0.634	.015	13	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CYB5R2–LGG (OS)

Open the LGG breakdown →