CXorf58

Across TCGA patient cohorts, CXorf58 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf58-associated genes across cancer lineages are TFRC, EGFR_pY1068, and eIF4E. Each is linked with CXorf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXorf58-to-partner and partner-to-CXorf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CXorf58-low versus CXorf58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf58→partner) and Y-score (partner→CXorf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.629	+3.807	.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.185	-1.502	.045	.030	3	1
UCEC	eIF4E →	+0.159	+3.183	.040	.009	3	1
UCEC	ACC1 →	+0.303	+1.502	.023	.030	3	1
UCEC	JNK2 →	+0.216	+2.817	.003	.001	3	1
UCEC	Ku80 →	+0.308	+2.331	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by CXorf58 expression — UCEC

Explore this box plot interactively →