CXXC1

Across TCGA patient cohorts, CXXC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,274 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CXXC1-associated genes across cancer lineages are ZNF747, ZNF594, and ZNF397. Each is linked with CXXC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CXXC1-to-partner and partner-to-CXXC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CXXC1 versus ZNF747 in HNSC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC1→partner) and Y-score (partner→CXXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF747 →	+0.437	+0.141	.002	.002	3	6
UCEC	ZNF594 →	+0.538	+0.145	<.001	.002	3	6
HNSC	ZNF397 →	+0.706	+0.244	<.001	<.001	3	6
GBM	CEP95 →	+0.595	+0.375	<.001	<.001	3	6
BRCA	C8orf44 →	+0.549	+0.190	<.001	<.001	3	6
LSCC	ZADH2 →	+0.498	+0.212	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,274 associations by consensus.

CXXC1 vs ZNF747 — HNSC

Explore this scatter interactively →