CXXC1

Across TCGA pan-cancer cohorts, CXXC1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CXXC1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CXXC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXXC1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LIHC, KICH, and KIRC are the cancer types where CXXC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXXC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.068	<.001	9	view →
KICH	Female	All	−1.346	<.001	8	view →
KIRC	Female	All	+0.514	<.001	7	view →
HNSC	All	All	+0.366	.004	7	view →
THCA	All	All	−0.241	<.001	7	view →
CHOL	All	All	+1.925	<.001	5	view →
STAD	Male	II,III,IV	+0.677	.003	5	view →
LUSC	All	All	+0.344	.004	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CXXC1–LIHC

Open the LIHC breakdown →