CXXC1

Across TCGA pan-cancer cohorts, CXXC1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CXXC1 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CXXC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CXXC1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRP show a favorable association.

ACC, LIHC, and KICH are the cancer types where CXXC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.266	0.635	<.001	117	view →
LIHC	OS	Tertile	All	0.397	0.617	<.001	76	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	60	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	48	view →
KIRP	OS	Tertile	All	0.978	0.877	.002	21	view →
MESO	OS	Quartile	III,IV	0.354	0.606	.005	21	view →
LUSC	DFS	Median	III,IV	0.212	0.758	.014	21	view →
PAAD	DFS	Quartile	All	0.446	0.124	.003	21	view →
GBM	DFS	Median	All	0.382	0.195	.003	16	view →
SKCM	DFS	Tertile	III,IV	0.120	0.452	.005	15	view →
CHOL	OS	Tertile	All	1.000	0.165	.003	13	view →
LUAD	DFS	Tertile	IV	0.238	0.896	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CXXC1–ACC (DFS)

Open the ACC breakdown →