CXXC1

Across TCGA patient cohorts, CXXC1 mutation is significantly associated with the RNA expression of many other genes, with 3,370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXXC1-associated genes across cancer lineages are RNU6-1029P, ABHD3, and MVD. Each is linked with CXXC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXXC1-to-partner and partner-to-CXXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1029P grouped by CXXC1-low versus CXXC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC1→partner) and Y-score (partner→CXXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1029P →	+0.261	+3.797	.002	.003	3	3
UCEC	ABHD3 →	+0.585	+1.698	<.001	<.001	3	3
UCEC	MVD →	+0.479	+1.720	<.001	<.001	3	3
UCEC	CWF19L1 →	+0.327	+1.709	<.001	<.001	3	3
UCEC	CCND1 →	+0.818	+2.279	<.001	<.001	3	3
UCEC	RPL23AP90 →	+0.196	+1.336	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,370 associations by consensus.

RNU6-1029P by CXXC1 expression — COAD

Explore this box plot interactively →