CXXC1

Across TCGA patient cohorts, CXXC1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXXC1-associated genes across cancer lineages are Cyclin-B1, ERK2, and MEK1. Each is linked with CXXC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXXC1-to-partner and partner-to-CXXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CXXC1-low versus CXXC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC1→partner) and Y-score (partner→CXXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.633	+3.087	<.001	<.001	3	3
UCEC	ERK2 →	+0.158	+2.584	.013	.010	3	2
UCEC	MEK1 →	+0.258	+1.765	.032	.013	3	2
UCEC	p27_pT198 →	+0.089	+1.652	.011	.006	3	2
UCEC	TFRC →	+0.443	+2.459	.011	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.661	+2.189	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-B1 by CXXC1 expression — UCEC

Explore this box plot interactively →