CXXC1

Across TCGA cell cohorts, CXXC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,642 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CXXC1-associated GO terms across cancer lineages are Centriole assembly, Regulation of DNA repair, and DNA methylation-dependent constitutive heterochromatin formation. Each is linked with CXXC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CXXC1-to-partner and partner-to-CXXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole assembly grouped by CXXC1-low versus CXXC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC1→partner) and Y-score (partner→CXXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Centriole assembly →	+0.142	+1.105	<.001	<.001	3	15
BONE	Regulation of DNA repair →	+0.089	+0.949	<.001	.001	3	14
SOFT_TISSUE	DNA methylation-dependent constitutive heterochromatin formation →	+0.120	+1.017	<.001	<.001	3	13
BONE	Positive regulation of DNA metabolic process →	+0.103	+1.072	<.001	<.001	3	13
BONE	Chromosome separation →	+0.232	+1.078	<.001	<.001	3	13
BREAST	Spindle localization →	+0.097	+0.932	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,642 associations by consensus.

Centriole assembly by CXXC1 expression — BONE

Explore this box plot interactively →