CXXC1

Across TCGA cell cohorts, CXXC1 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CXXC1-associated genes across cancer lineages are ARFRP1, CCNG1, and TXNDC15. Each is linked with CXXC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXXC1-to-partner and partner-to-CXXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARFRP1 grouped by CXXC1-low versus CXXC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC1→partner) and Y-score (partner→CXXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARFRP1 →	-0.655	-3.278	.006	.006	3	1
LARGE_INTESTINE	CCNG1 →	+0.985	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TXNDC15 →	+0.657	+3.364	.001	.002	3	1
LARGE_INTESTINE	PCCB →	+0.583	+3.451	.002	.002	3	1
LARGE_INTESTINE	SSX2IP →	+0.936	+3.169	.001	.009	3	1
LARGE_INTESTINE	CR2 →	+0.657	+3.363	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

ARFRP1 by CXXC1 expression — LARGE_INTESTINE

Explore this box plot interactively →