CXCR5

Across TCGA patient cohorts, CXCR5 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR5-associated genes across cancer lineages are RPL36P1, RN7SKP43, and MIR7-3. Each is linked with CXCR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR5-to-partner and partner-to-CXCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL36P1 grouped by CXCR5-low versus CXCR5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR5→partner) and Y-score (partner→CXCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL36P1 →	+0.285	+4.821	<.001	.003	3	2
COAD	RN7SKP43 →	+0.196	+5.412	<.001	.001	3	2
CESC	MIR7-3 →	+0.275	+5.342	<.001	.002	3	2
SKCM	PSMB7P1 →	+0.053	+4.884	<.001	.004	3	2
CESC	LINC02087 →	+0.049	+4.409	.001	.006	3	1
CESC	PIEZO1P2 →	+0.021	+4.816	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

RPL36P1 by CXCR5 expression — COAD

Explore this box plot interactively →