CXCR5

Across TCGA pan-cancer cohorts, CXCR5 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CXCR5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CXCR5 RNA is repressed in tumor relative to normal tissue. In most cancer types CXCR5 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BRCA, and BLCA are the cancer types where CXCR5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCR5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.365	<.001	8	view →
BRCA	All	All	+0.103	<.001	6	view →
BLCA	All	III,IV	−0.270	.019	4	view →
LUAD	Female	II,III,IV	+0.164	.001	3	view →
KIRC	All	All	+0.044	.002	3	view →
THCA	All	All	−0.248	.010	2	view →
CHOL	All	All	+0.046	.034	2	view →
STAD	Female	III,IV	+1.585	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CXCR5–COAD

Open the COAD breakdown →