CXCR4

Across TCGA patient cohorts, CXCR4 mutation is significantly associated with the RNA expression of many other genes, with 1,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR4-associated genes across cancer lineages are NPIPA2, MSRB1P1, and NBEAP3. Each is linked with CXCR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXCR4-to-partner and partner-to-CXCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPIPA2 grouped by CXCR4-low versus CXCR4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR4→partner) and Y-score (partner→CXCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NPIPA2 →	+0.054	+7.640	<.001	.009	3	3
SKCM	MSRB1P1 →	+0.146	+2.917	<.001	.002	3	2
SKCM	NBEAP3 →	+0.040	+2.504	<.001	.007	3	2
READ	UPP2-IT1 →	+0.143	+5.039	<.001	.008	3	2
LGG	RNA5SP285 →	+0.295	+6.032	<.001	.002	3	2
LGG	MIR3922 →	+0.515	+5.602	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

NPIPA2 by CXCR4 expression — BLCA

Explore this box plot interactively →