CXCR4

Across TCGA pan-cancer cohorts, CXCR4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CXCR4 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CXCR4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CXCR4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, UVM, and LUAD are the cancer types where CXCR4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.667	0.486	<.001	76	view →
UVM	DFS	Median	All	0.420	0.744	<.001	66	view →
LUAD	OS	Median	II,III,IV	0.718	0.463	<.001	60	view →
OV	OS	Median	All	0.366	0.279	.010	50	view →
LGG	OS	Tertile	All	0.714	0.856	<.001	39	view →
KIRP	DFS	Tertile	All	0.551	0.952	.001	38	view →
ESCA	DFS	Tertile	II,III,IV	0.629	0.385	.004	32	view →
SKCM	OS	Quartile	All	0.820	0.699	.004	32	view →
STAD	OS	Median	All	0.514	0.649	.007	31	view →
DLBC	DFS	Tertile	All	0.371	1.000	.009	22	view →
MESO	OS	Median	III,IV	0.317	0.518	.018	20	view →
ACC	DFS	Quartile	All	0.277	0.843	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CXCR4–HNSC (DFS)

Open the HNSC breakdown →