CXCR4

Across TCGA pan-cancer cohorts, CXCR4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CXCR4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CXCR4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXCR4 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, STAD, and BRCA are the cancer types where CXCR4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCR4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.248	<.001	12	view →
STAD	All	All	+1.448	<.001	7	view →
BRCA	All	III,IV	+1.314	<.001	6	view →
LUSC	Male	All	−0.813	.005	5	view →
HNSC	All	II,III,IV	+0.775	.005	5	view →
KIRP	Male	All	+1.439	<.001	3	view →
ESCA	All	All	+2.001	.006	2	view →
CHOL	All	All	+1.647	.007	2	view →
LIHC	Female	II,III,IV	+1.364	.009	2	view →
UCEC	All	All	+0.940	.021	2	view →
LUAD	Female	All	+0.444	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CXCR4–KIRC

Open the KIRC breakdown →