CXCR4

Across TCGA patient cohorts, CXCR4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR4-associated genes across cancer lineages are ASNS, 14-3-3_beta, and eIF4E. Each is linked with CXCR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXCR4-to-partner and partner-to-CXCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CXCR4-low versus CXCR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR4→partner) and Y-score (partner→CXCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.443	+2.321	.005	.034	3	2
UCEC	14-3-3_beta →	-0.104	-3.143	.018	.018	3	1
UCEC	eIF4E →	+0.208	+2.115	.024	.019	3	1
UCEC	Ku80 →	+0.222	+1.598	.031	.044	3	1
UCEC	MEK1 →	+0.399	+2.321	.012	.034	3	1
UCEC	MSH2 →	-0.283	-2.295	.005	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ASNS by CXCR4 expression — UCEC

Explore this box plot interactively →