CXCR4

Across TCGA cell cohorts, CXCR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,167 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CXCR4-associated GO terms across cancer lineages are Sphingolipid catabolic process, Positive regulation of DNA repair, and Regulation of cytoplasmic mRNA processing body assembly. Each is linked with CXCR4 in more than 6 cancer types. Because this analysis shows association rather than direction, both CXCR4-to-partner and partner-to-CXCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingolipid catabolic process grouped by CXCR4-low versus CXCR4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR4→partner) and Y-score (partner→CXCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sphingolipid catabolic process →	-0.191	-2.686	<.001	.009	3	7
BONE	Positive regulation of DNA repair →	+0.065	+1.744	.001	.009	3	7
BLOOD_Lymphoma	Regulation of cytoplasmic mRNA processing body assembly →	+0.098	+2.780	<.001	.001	3	7
LIVER	Negative regulation of nervous system process →	+0.136	+1.601	.003	.006	3	6
LUNG_SCLC	Regulation of interleukin-8 production →	-0.106	-3.276	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Positive regulation of calcium ion transmembrane transport →	-0.134	-0.735	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,167 associations by consensus.

Sphingolipid catabolic process by CXCR4 expression — BONE

Explore this box plot interactively →