CXCR4

Across TCGA cell cohorts, CXCR4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CXCR4-associated genes across cancer lineages are LMNTD1, PPDPFL, and HSFY2. Each is linked with CXCR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR4-to-partner and partner-to-CXCR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNTD1 grouped by CXCR4-low versus CXCR4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR4→partner) and Y-score (partner→CXCR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMNTD1 →	+0.179	+2.969	<.001	.007	3	1
LARGE_INTESTINE	PPDPFL →	+0.039	+3.217	<.001	.006	3	1
LARGE_INTESTINE	HSFY2 →	+0.011	+3.562	<.001	.002	3	1
LARGE_INTESTINE	OR5AK2 →	+0.034	+3.700	<.001	.009	3	1
LARGE_INTESTINE	RPS4Y2 →	+0.017	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBL1Y →	+0.115	+3.217	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LMNTD1 by CXCR4 expression — LARGE_INTESTINE

Explore this box plot interactively →