CXCL13

Across TCGA patient cohorts, CXCL13 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL13-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and GATA6. Each is linked with CXCL13 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL13-to-partner and partner-to-CXCL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CXCL13-low versus CXCL13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL13→partner) and Y-score (partner→CXCL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-3.143	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.322	-2.459	.004	.019	3	1
UCEC	GATA6 →	-0.235	-3.577	.001	.002	3	1
UCEC	Heregulin →	-0.136	-2.321	.014	.034	3	1
UCEC	INPP4B →	-0.365	-1.986	.012	.032	3	1
UCEC	Ku80 →	+0.279	+2.713	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by CXCL13 expression — UCEC

Explore this box plot interactively →